Adelie penguin liver P450 enzymes
Entry ID: K065_1996_1998_NZ_1

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Summary
Abstract: Animlas can be harmed by artificially introduced chemicals either through the food chain or directly. This study aimed to determine how penguins detoxify chemical pollutants they may be exposed to. Liver samples were collected from Adelie penguins from Cape Bird, Cape Royds and Cape Crozier, both adults (10) and chicks (20). The samples were analysed for liver enzymes with the aim to characterize different P450 enzymes involved in biotransformation and detoxification of chemical pollutants. The aim is to determine the susceptibility of Antarctic penguins to environmental chemicals.
Geographic Coverage
Spatial coordinates   
  N: -77.0   S: -78.0   E: 170.0   W: 166.0

Temporal Coverage
Start Date: 1996-12-07
Stop Date: 1996-12-13

Start Date: 1998-01-06
Stop Date: 1998-01-17
ISO Topic Category
Quality Existing liver samples are held at the laboratory at Loma Lida University, California, USA for use in further studies. Please contact the investigator for more information.
Data Set Progress
COMPLETE
Originating Center
Data Center
Antarctica New Zealand, New Zealand Antarctic Institute, New Zealand Supplemental Info
Data Center URL: http://www.antarcticanz.govt.nz/

Data Center Personnel
Name: SHULAMIT GORDON
Phone: +64 3 358 0200
Fax: +64 3 358 0211
Email: s.gordon at antarcticanz.govt.nz
Contact Address:
Antarctica New Zealand
Private Bag 4745
City: Christchurch
Country: New Zealand
Personnel
Role: INVESTIGATOR
Phone: 001 909 558 7729
Fax: 001 909 558 7927
Email: swanwimolruk at llu.edu
Contact Address:
School of Pharmacy
Loma Linda University
City: Loma Linda
Province or State: California
Postal Code: 92350
Country: USA
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Publications/References
Wanwimolruk, S. Zhang, H. Coville, P.F. Saville, D.J. Davis, L.S. In vitro hepatic metabolism of a CYP3A-mediated drug, quinine, in Adélie penguins. Comparative Biochemistry and Physiology 124C: 310-307, 1999.

Wanwimolruk S, Wanwimolruk P. Characterization of CYP1A enzyme in Adelie penguin liver. Compar. Biochem. Physiol. 144C: 148-154 (2006).

Numata M, Fawcett JP, Rosengren RJ, Wanwimolruk S. Ontogeny of hepatic microsomal 3-hydroxylation of quinine mediated by CYP3A in Adelie penguins. Compar. Biochem. Physiol. 138C: 53-58 (2004).
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Creation and Review Dates
DIF Creation Date: 2005-11-01
Last DIF Revision Date: 2009-03-27
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