EPA's Toxicity Reference DatabaseEntry ID: EPA_ToxRefDB
Abstract: ToxRefDB was developed by the National Center for Computational Toxicology (NCCT) in partnership with EPA's Office of Pesticide Programs (OPP), to store data from in vivo animal toxicity studies. The database:
-Contains pesticide registration toxicity data that used to be stored as hard-copy and scanned documents by OPP.
-Currently includes chronic, cancer, sub-chronic, developmental, and ... reproductive studies on hundreds of chemicals (many are pesticide active ingredients).
-Provides data that is accessible and computable.
-Provides reference toxicity data for Agency research and retrospective analyses.
-Provides toxicity endpoints for development of ToxCast predictive signatures that will be used for primary research applications.
-Contains only certain hazard information and does not represent all information needed for a complete risk assessment for pesticides or other chemicals.
-Effect designation should not be taken as determination that existing EPA risk assessments and risk management decisions need revisions.
For example, in addition to studies in ToxRefDB, for purposes of registration or tolerance determination, EPA evaluated information on other mammalian toxicity effects, metabolism, aquatic life, wildlife and plant toxicity studies, and use patterns, environmental fate and persistence, and pesticide residue levels.
Purpose: ToxRefDB (Toxicity Reference Database) captures thousands of in vivo animal toxicity studies on hundreds of chemicals. The database:
-Stores detailed study design, dosing, and observed treatment-related effects using standardized vocabulary.
-Provides detailed chemical toxicity data, for the first time, in a publically accessible and searchable format.
-Enables linkages to other public hazard, ... exposure and risk resources by integrating with ACToR (Aggregated Computational Toxicology Resource).
-Captures over 30 years and $2 billion of animal testing results.
-Allows users to search and query data from other EPA chemical toxicity databases including ToxRefDB, ToxCastDB, and DSSTox.
-ToxRefDB has currently released detailed study and effect information on 474 chemicals, primarily the data rich pesticide active ingredients, and will continue to expand. If there are no available studies in ToxRefDB, please search for the chemical of interest in ACToR for all publicly available hazard, exposure, and risk information.
-Additional chemical toxicity data will be released soon for additional conventional pesticides, antimicrobials, commodity chemicals and pharmaceuticals from previously unpublished and public literature studies.
ISO Topic Category
Use Constraints In ToxRefDB, toxicity study information is organized into four main tiers, chemical,
study design, treatment group (animal) dosing information, and effects (i.e., endpoints).
The “Search By Endpoint” page allows for flexible querying of the database for specific
effects or sets of effects of interest. Since ToxRefDB captures on the treatment-related
effects, the absence ... of an effect in the database is assumed to be a negative. This
assumption is not always true and this should be considered whenever retrieving data
Based on the standardized vocabulary, there is a defined set of terms for capturing the
effect information on any given study. This vocabulary is constantly growing and
changing based on feedback from subject matter experts. The top tier is the study type
which consists of subchronic (SUB), chronic/cancer (CHR), reproductive (MGR), and
developmental (DEV) studies. Each of these studies has been tested in rat, mouse and/or
rabbit. Each unique effect is determined based on the combination of the Effect Type,
Effect Target, Effect Description, and Effect Direction.
Extended Metadata Properties
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Creation and Review Dates
DIF Creation Date: 2013-09-15
Last DIF Revision Date: 2014-01-26