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EPA's Toxicity Reference Database
Entry ID: EPA_ToxRefDB

Abstract: ToxRefDB was developed by the National Center for Computational Toxicology (NCCT) in partnership with EPA's Office of Pesticide Programs (OPP), to store data from in vivo animal toxicity studies. The database:

-Contains pesticide registration toxicity data that used to be stored as hard-copy and scanned documents by OPP.
-Currently includes chronic, cancer, sub-chronic, developmental, and ... View entire text

Purpose: ToxRefDB (Toxicity Reference Database) captures thousands of in vivo animal toxicity studies on hundreds of chemicals. The database:

-Stores detailed study design, dosing, and observed treatment-related effects using standardized vocabulary.
-Provides detailed chemical toxicity data, for the first time, in a publically accessible and searchable format.
-Enables linkages to other public hazard, ... View entire text
Related URL
Description: ToxRefDB data can be downloaded from this link
Use Constraints In ToxRefDB, toxicity study information is organized into four main tiers, chemical,
study design, treatment group (animal) dosing information, and effects (i.e., endpoints).
The ?Search By Endpoint? page allows for flexible querying of the database for specific
effects or sets of effects of interest. Since ToxRefDB captures on the treatment-related
... View entire text
Data Center
National Center for Computational Toxicology, U.S. Environmental Protection Agency Supplemental Info
Data Center URL:

Data Center Personnel
Phone: 919-541-4104
Fax: 919-685-3399
Email: actor_suppport at
Contact Address:
109 T.W. Alexander Drive (B205-01)
City: Research Triangle Park
Province or State: North Carolina
Postal Code: 27711
Country: USA
Extended Metadata Properties
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Creation and Review Dates
DIF Creation Date: 2013-09-15
Last DIF Revision Date: 2017-08-23